Effect of Prosopis africana Seed Extract on Histology and Biochemical Indices of Prostate Functions in Testosterone and Estradiol induced Enlarged Prostate in Adult Rats

by Ugwu, Melvin N.(1), Eteng, Mbeh U.(2), Ogueche, Peter N.(3), Amaku, Etetim E.(4)


Abstract: Benign prostatic hyperplasia (BPH) is characterized as a slow, progressive enlargement of the prostate gland, which eventually causes obstruction and subsequent problems with urination. We investigated seed extract of Nigerian indigenous plant Prosopis africana (PA) effect on BPH. BPH was induced in male rats weighing 250-350g through exogenous administration of testosterone and estradiol. A total of 25 rats were divided into five groups. One group was used as a control and the other groups received subcutaneous injections of the two hormones. Groups 1 to 2 were treated orally with different doses of extracts and group 3 received finasteride, group 4 was left untreated and group 5 served as normal control. After forty-five days of treatment with the extract the animals were sacrificed blood collected through cardiac puncture for biochemical analysis. The prostate were harvested and processed for paraffin embedding and stained with H and E. Treatment with the extract and finasteride resulted to significant (P < 0.05) decrease in prostate specific antigen (PSA), estradiol and prolactin and testosterone when compared to BPH control. Also there was a significant increase in the protein content of the prostate when compared to BPH control. Prostate weight was significantly (P < 0.05) reduced in treated groups compared to BPH control. This was supported by the histological examination of the prostate. Therefore, Prosopis africana was effective in reducing PSA, prolactin, testosterone, estradiol and prostate weight induced BPH in a rat model, and may be useful for the clinical treatment of patients with BPH. Keywords PSA, prolactin, testosterone and estradiol and prostate


1 – Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Cross River University of Technology, Calabar, Nigeria
2 – Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Nigeria
3 – Department of Human Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
4 – Department of Human Physiology, Faculty of Basic Medical Sciences, Cross River University of Technology, Calabar, Nigeria

Prof Mbeh Eteng

Mbeh Eteng is a Professor of Biochemistry in the Faculty of University of Calabar. He holds a Ph.D from the University of Calabar (2000). He was Dean of Faculty of Basic Medical Science (2012-2016) and Chairman Committee of Deans (2014-2015). Member Governing Board UCTH, Calabar (2018 -till date). Fellow, Institute of Co-operate Administration. His current area of research is on malaria/prostrate hyperplaxia and medicinal plants research and use in management. He has successfully supervised 25 Ph.Ds.
Get to know more about him and access more of his publications through his personal knowledgebase – http://www.mbeheteng.com.ng

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