Interaction with iodine metabolism following ingestion of Allium Cepa and Allium Sativum by albino wistar rats

by Eteng Mbeh U.(1) and Aletan, Uduak I.(2)


The interaction with iodine metabolism following ingestion of Allium cepa (onion) and Allium sativum (garlic) by albino Wistar rats have been studied. The determination of the effect of the oral administration of onion and garlic extract on thyroid hormones (triidothyronine,T3, thyroxine,T4 were studied. The mean values of triiodothyronine (T3) for the experimental animals were 1.23 ± 0.09ng/ml for the control group and 0.97 ± 0.13ng/ml for iodine treated high dose garlic group. Compared to the control, administration of onion and garlic led to a statistically significant (P < 0.05) decrease in T3 of both normal and iodine treated rats. The mean values of thyroxine, T4, for the experimental animals was found to be 1.19 ± 0.12 IU/ml and 0.85 ± 0.16 IU/ml for the low dose onion normal rats and low dose garlic normal rats respectively. Except for the groups administered with low dose onion, oral administration of onion and garlic extract led to a significant ( P < 0.05) decrease in the thyroxine level of both normal and iodine treated rats. These results are discussed in relation to the harmful and beneficial effects of onion and garlic consumption to public health.
Key Words: Iodine metabolism, Allium cepa (onion), Allium sativum (garlic)


1 – Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Cross River State, Nigeria
2 – School of Science and Technology, National Open University of Nigeria, Lagos, Nigeria

Prof Mbeh Eteng

Mbeh Eteng is a Professor of Biochemistry in the Faculty of University of Calabar. He holds a Ph.D from the University of Calabar (2000). He was Dean of Faculty of Basic Medical Science (2012-2016) and Chairman Committee of Deans (2014-2015). Member Governing Board UCTH, Calabar (2018 -till date). Fellow, Institute of Co-operate Administration. His current area of research is on malaria/prostrate hyperplaxia and medicinal plants research and use in management. He has successfully supervised 25 Ph.Ds.
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