Effect of Vitamin C and Recovery Period of Endosulfan (thionex 35ec) Induced Toxicity in Albino Wistar Rats

by Eteng, M. U, Asuquo, E. N, Amali, O. O. E, Obochi, G. O, Ochalefu, D. O. and Myke-Mbata, B. K.

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Abstract
The study was designed to evaluate the effect of vitamin C and recovery period on wistar albino rats exposed to endosulfan (thionex 35EC) through inhalation and oral methods. Thirty wistar albino rats procured from the animal house of the Department of Biochemistry, University of Calabar, Nigeria were used for the study. The rats were divided into six groups of five rats per group. Group I served as control, while group Il was given vitamin C only. Groups II! and IV received endosulfan through inhalation and oral methods respectively. Group V received endosulfan orally plus vitamin C for five weeks while group VI also received endosulfan Orally for five weeks then withdrawn from exposure to endosulfan and allowed another five weeks to recover. The results showed that the serum liver enzymes, including alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP) and creatine kinase (CK) activities; liver tissue malonyldialdehyde (MDA)
level, serum renal function metabolites (including creatinine, urea, uric acid, and potassium ion)
concentrations, white blood cell counts, total serum cholesterol, triacylglycerol, very low density lipoproteins and bilirubin concentrations obtained for rats in groups Ill and IV were significantly higher (p=0.05), while haematological indices including haemoglobin concentration, packed cell volume and red blood cell counts, total serum protein as well as serum high density lipoprotein obtained for these groups were significantly lower (p=0.05) compared respectively with the control group. The result indicates that the toxicity effects of endosulfan are not dependent on the routes of exposure (groups Ill and IV). The concentrations of the assayed parameters were also not significantly different (p=05) within and among groups I, V and VI. These results therefore indicated that the toxicity effects observed to be induced by endosulfan (groups III and IV) were ameliorated by vitamin C (group V) and reversed when given sufficient time to recover (group VI) when compared to the control (group I). It can be concluded from this study that endosulfan induces
toxicity effects in Wistar albino rats.

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Mbeh Eteng is a Professor of Biochemistry in the Faculty of University of Calabar. He holds a Ph.D from the University of Calabar (2000). He was Dean of Faculty of Basic Medical Science (2012-2016) and Chairman Committee of Deans (2014-2015). Member Governing Board UCTH, Calabar (2018 -till date). Fellow, Institute of Co-operate Administration. His current area of research is on malaria/prostrate hyperplaxia and medicinal plants research and use in management. He has successfully supervised 25 Ph.Ds.
Get to know more about him and access more of his publications through his personal knowledgebase – http://www.mbeheteng.com.ng

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