THEOBROMIINE ADMINISTRATION INHIBITS PLATELET AGGREGATION AND ELEVATES SERUM HDL-CHOLESTEROL IN HYPERLIPIDEMIC WISTAR RATS

BY M. U. ETENG, EBONG, P. E. EBONG, R. R. ETTARH, E. DAVID-OKU and I. B. UMOH

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ABSTRACT

Pure theobromine was administered by oral gavage to hyperlipidemic Wistar rats weighing 100-250g for a four-day period Serum lipid profiles, body weight changes and extent of platelet aggregation were assessed in these animals against appropriate controls. Theobromine administration in moderate (600mg/kg body weight) to high (700mg/kg body weight) doses, produced a significant (P <0.05, and P <0.001) dose and time dependent decrease in triglyceride, LDL-cholesterol and VLDL-cholesterol concentration and a significant (P < 0.001) increase in HDL-cholesterol level relative controls. The results also indicate a significant (P <0.001) increase in platelet count ratio in the theobromine treatment groups with values of 0.89 ± 0.08 and 0.99 ± 0.05 for the 600mg/kg and 700mg/kg theobromine dose regimens respectively, relative. to the control value of 0.84 ± 011. The increase in the ratio indicates absence of aggregation; thus theobromine inhibits platelet aggregation and elevates plasma HDL-cholesterol levels in hyperlipidemic Wistar rats. The implications of these findings are discussed in relation to the therapeutic potentials of theobromine in the treatment of hyperlipidemia, and its ability to impede atherogenesis.
Key Words: Theobromine, hyperlipidemia, platelet-aggregation, HDL-cholesterol, atherogenesis.

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THEOBROMIINE ADMINISTRATION INHIBITS PLATELET AGGREGATION AND ELEVATES SERUM HDL-CHOLESTEROL IN HYPERLIPIDEMIC WISTAR RATS BY M. U. ETENG, EBONG, P. E. EBONG, R. R. ETTARH, E. DAVID-OKU and I. B. UMOH

Prof Mbeh Eteng

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Mbeh Eteng is a Professor of Biochemistry in the Faculty of University of Calabar. He holds a Ph.D from the University of Calabar (2000). He was Dean of Faculty of Basic Medical Science (2012-2016) and Chairman Committee of Deans (2014-2015). Member Governing Board UCTH, Calabar (2018 -till date). Fellow, Institute of Co-operate Administration. His current area of research is on malaria/prostrate hyperplaxia and medicinal plants research and use in management. He has successfully supervised 25 Ph.Ds.
Get to know more about him and access more of his publications through his personal knowledgebase – http://www.mbeheteng.com.ng

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