Theobromine induced seminiferous tubular lesion with elevated serum testosterone levels in male Wistar rats

by Mbeh U. ETENG*, Eyong U. EYONG, G. O. IFERE and N. CHUKWUEMEKA

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Theobromine induced seminiferous tubular lesion with elevated serum testosterone levels in male Wistar rats

by Mbeh U. ETENG*, Eyong U. EYONG, G. O. IFERE and N. CHUKWUEMEKA

Abstract
Concentrations of serum testosterone, albumin, transferrin, total serum protein and testicular histology of male albino wistar rats were evaluated following administration of 700mg/kg body weight theobromine in 0.5ml 14% sodium acetate for seven days. Theobromine administration produced significant increase in serum testosterone concentration (P < 0.05) and significant decreases in serum albumin and total serum protein (P < 0.05) when compared with the controls. The decrease in serum transferrin was not significant (P > 0.05) compared with the control and there were seminiferous tubular lesions. The results suggest in part, structural damage on the tubules which may affect its function but the extent to which its function is impaired is not
known.
Key words: Theobromine, Seminiferous tubular lesion, Serum testosterone, proteins

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* Department of Biochemistry, College of Medical Sciences, University of Calabar,
Calabar, Nigeria

Prof Mbeh Eteng

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Mbeh Eteng is a Professor of Biochemistry in the Faculty of University of Calabar. He holds a Ph.D from the University of Calabar (2000). He was Dean of Faculty of Basic Medical Science (2012-2016) and Chairman Committee of Deans (2014-2015). Member Governing Board UCTH, Calabar (2018 -till date). Fellow, Institute of Co-operate Administration. His current area of research is on malaria/prostrate hyperplaxia and medicinal plants research and use in management. He has successfully supervised 25 Ph.Ds.
Get to know more about him and access more of his publications through his personal knowledgebase – http://www.mbeheteng.com.ng

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