Synthesis and Biological Activity of Platinum group metal complexes of O-vanillin thiosemicarbazones


Offiong O.E., C. A. Etok and S. Martelli (1996). IL FARMACO 51 (12): 801-808.

Summary — o-Vanillin-(4-rnethylthiosemicarbazone), o-Vanillin-(4-henylthiosemicarbazone) and some of their metal complexes of the platinum group have been synthesized, characterized by chemical and spectral methods and studied for their antibacterial, antifungal and amoebicidal activity in vitro. The platinum group metal chelates exibited significant activity against a wide spectrum of microorganisms at different concentrations. The Pt(II) and Ru(III) chelates derived from o-vanillin-(4-phenylthiosemicarbazone) seem to be the most efficient inhibitors. Evaluation of the antimalarial activity of the compounds in mice infected with Plasmodium berghei indicated that cures were attainable at dose
levels of 40-160 mg/kg but with toxic death prevalence at higher dose levels.

Prof. Comfort Etok

Professor Comfort Etok is a Professor of Microbiology from University of Uyo. Her area of specialization is Industrial/Food Biology. She has obtained her BSc, MSc. and Ph.D in Microbiology from University of Calabar..

She has been a recipient of several awards, one of which was the Professor Nduka Okafor’s prize for Best Graduating Student in Microbiology. She has served and is still serving in various committees in the University, State and National frontier. She has supervised and is still supervising intelligent undergraduate and postgraduate researches in Microbiology. One of such research worthy of note is “Fermentation And Amino Acid Profile Of Maize Pomace And Rice Husk And Their Dietary Effects On Broilers Chicken”.

She holds Membership in several Professional Bodies like American Society for Microbiolgy, Nigerian Society for Microbiology etc. She has published highly rated Journal Articles, Book Chapters etc. One of such publication shaking her field is “Bdellevibrio and Like Organisms: The much Anticipated “Magic Bullet”.” published by World News of National Science.
Visit her personal knowledgebase at to more about this great scholar.

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